What are the four mechanisms on how steroids produce osteoporosis?
Answers:
>>Steroids decrease the amount of calcium absorbed by the intestine and increases calcium excretion through the kidneys.
>>Those two factors combine to produce a decline in the circulating ionized calcium concentration.
>>That triggers the parathyroid glands to increase the secretion of parathyroid hormone (PTH).
>>Elevated PTH levels result to increased bone breakdown, as the body attempts to rectify low circulating calcium levels by releasing calcium from the bones into the blood.
==The result at the end of above mechanisms is OSTEOPOROSIS.
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