Can someone update of the use of PTH within bone osteoporosis?
Answers: It has now been all right over a year since the FDA approved PTH therapy for the treatment of osteoporosis. The only preparation available currently is brand name Forteo, which is recombinant human parathyroid hormone (rhPTH). It is key to recognize that this is human parathyroid hormone. Recombinant refers to the method of building the parathyroid hormone from amino acids (obtained from breaking down the molecular structure of microorganisms). The resulting structure is identical to that of the active bit of the human PTH hormone.
All of the existing treatments for osteoporosis, which include estrogen, selective estrogen and receptor modulators (Evista), bisphosphonates (Fosamax and Actonel) and calcitonin (Miacalcin) act by reducing loss of bone mineral. These are called antiresorptive agents. They do not build bone. By reducing loss of bone mineral, the result is that there is an increased mineralization (laying down of calcium and phosphate) contained by what is left of the basic bone structure, but there is no rebuilding the bone to be exact lost in osteoporosis. It is important to understand that osteoporosis refers to a total loss of bone compared to average. This would be a loss of calcium and phosphate, but also loss of the supporting structure, which is a protein matrix.
PTH therapy results in new bone formation contained by that there is a laying down of protein matrix, and mineralization occurs not single in the previous existing matrix, but in the new structure i.e. formed. PTH increases bone turnover, and it increases formation of bone more than resorption. The results of this are documented by an increase of bone density as measured at the osteoporosis center(s), but also a decrease in fracture compared to other forms of treatment. There is a 65-69 percent reduction within the chance of a new fracture in a soul with osteoporosis, and a 77-86 percent reduction in the adjectives of a recurrent fracture in a person near osteoporosis.
Continuous elevation of parathyroid hormone (PTH) levels occurs in humans due to peculiar secretion of this hormone from the parathyroid glands located in the neck. This is called hyperparathyroid disease. Loss of bone mass occur with resulting osteoporosis. However, intermittent elevation of PTH that occurs in the day by day injections of PTH, as prescribed in the use of Forteo.
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http://opocenter.com/updates/update4.htm
Cheers *Nike*
when treating osteoporosis, one must look at the cause. while Forteo is a good drug, one have to take it over a period of three years, at a cost of over Rs. 20000.00 per month! better to look for cost effective solutions. Don't know nearly that, but do know that Nikken released a supplement last month that is actually shown to INCREASE bone density. It uses innate ingredients, so it's completely safe. What it does is helps the body use nutrients more effectively- helps them occupy new nutrients and release the old ones. It is available without a prescription, and you'd thieve it daily in addition to a calcium supplement. Let me know if you'd close to more info about it!
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