What are the inheritance of osteoporosis?
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- Can you be born next to osteoporosis?
- I own osteoporosis and hold be taking OTC calcium, Today my doctor said to embezzle Caltrate 600. Why?
- Does calcium lend a hand bones or does it assist osteoporosis?
Progress in the study of the genetics of osteoporosis has be slow. Fractures are uncommon in individuals, occurring at a rate of 4-10 women/100 women per year in the topmost risk category. Thus, the feasibility of detecting associations between fractures and candidate genes is unlikely. Bone mineral density (BMD) is a predictor of fracture, but association studies with nominee genes -- such as vitamin D receptor (VDR), estrogen receptor, androgen receptor, and collagen type 1 alpha 1 (COL1A-1) -- have produced inconsistent and contradictory observations.[1] When associations are reported, only about 1% of population variance within BMD is explained, invalidating the use of polymorphisms as predictors of fracture risk. BMD is a summation of preinstall and endosteal (endocortical, intracortical, trabecular) surface remodeling; each component is independently regulated. BMD is too crude a measure to detect differences in surface remodeling due to genetic instability.
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Osteoporosis is most often considered a bone disorder of postmenopausal women, but men and younger women can also be affected. Overall, women are five times more feasible than men to develop osteoporosis, but 4-5 million men in the U.S. have or are at risk for the disorder. However, where the spinal bones are concerned, women are eight times more prone than men to vertebral osteoporosis.
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