What is bone resorption and bone formation contained by osteoporosis pathology?
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What a great question! Osteoporosis is fundamentally caused by an imbalance contained by the delicate system that maintains our bones.
- Osteoporosis medicine?
- How do you know if you are prone to osteoporosis?
- How prehistoric do you enjoy to be to take osteoporosis and is in attendance a intermingle between it and tooth decomposition?
Normally, cells call osteoclasts (responding to a hormone called PTH) break down old bone, reabsorb it, and then cell called osteoblasts lay down new bone.
This process continues every minute of every day of our lives - bone is constantly anyone broken down, recycled, and rebuilt (the term we use for this is 'remodeling').
In osteoporosis, a disease marked by decrease bone mineral density (BMD), this balance between bone breakdown and bone rebuilding is dysfunctional. There are 3 reasons for why/how osteoporosis happens:
1. Something call "peak bone mass" is insufficient. This means that your bones simply don't have the strength to support the required mass. This usually happens during growth (birth to a few years post-puberty).
2. Too much bone resorption. If too much bone is being chewed up and recycled, then the strength of your bones decrease.
3. Not enough new bone being laid down. If osteoblasts aren't doing their errand (for whatever reason), then your bones will also be weak.
A tremendous amount of research have gone into better understanding these 3 problems, but the take home message is that osteoporosis is complex. Treatment is also complicated, but fundamentally aims to increase the amount of calcium available for bone formation and to prevent osteoclasts from breaking down bone (this is what the bisphosphonates like Fosamax do - they butcher osteoclasts).
Wow - great question and long answer. Hope this helps!
bone resorption is too high
bone formation is too low
The bone is not human being produced as fast as it is being destroyed. the destruciton and rebuilding is constant, but it's unbalanced surrounded by osteoporosis.
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