What does elevated proteins in spinal fluid mean?
Answers:
What abnormal results mean:Cerebral spinal fluid (CSF) collection is a test to sample and measure pressure in the fluid that surrounds the brain and spinal cord. Cerebral spinal fluid acts like a cushion, protecting the brain and spine from injury. The fluid is normally clear.
Pressure, increased: increased intracranial pressure (pressure within the skull) from trauma or infection
Pressure, decreased: obstruction to the flow of CSF above the puncture site (spinal cord tumor), shock, fainting, diabetic coma
Appearance
Cloudy: infection, white blood cells in the CSF, protein in the CSF, microorganisms
Bloody or reddish colored: bleeding within the brain or subarachnoid space, spinal cord obstruction, traumatic lumbar puncture (first specimen bloody, rest clear)
Brown, orange, yellow color: elevated protein in the CSF, old (greater than 3 days) blood in the CSF
Protein, increased: blood in the CSF, diabetes, polyneuritis, tumors, trauma, any inflammatory or infectious condition
Protein, decreased: rapid CSF production
Gamma globulin, increased: demyelinating disease such as multiple sclerosis, neurosyphilis, Guillain-Barre syndrome
Glucose, increased: systemic hyperglycemia (elevated blood sugar)
Glucose, decreased: systemic hypoglycemia (low blood sugar), bacterial or fungal infection (such as meningitis), tuberculosis, carcinomatous meningitis
WBC, increased: active meningitis, acute infection, beginning of a chronic illness, tumor, abscess, brain infarction (stroke), demyelinating disease (such as multiple sclerosis)
RBC: bleeding into the spinal fluid, traumatic lumbar puncture
Additional conditions under which the test may be performed:
Chronic inflammatory polyneuropathy
Dementia due to metabolic causes
Encephalitis
Epilepsy
Febrile seizure (children)
Generalized tonic-clonic seizure
Hydrocephalus
Inhalation anthrax
Normal pressure hydrocephalus (NPH)
Pituitary tumor
Reye's syndrome
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