Why should a normal spinal tap of CSF not show antibodies? I know that a presense may indicate MS..?
I have to explain why normal CSF doesn't contain antibodies. It is for a case study that is due tomorrow...I have exausted all other resources.
Answers:
Antibodies induce an inflammatory response when you have an infection. Your CSF doesn't contain antibodies (Abs) because unlike your body, your central nervous system (CNS:brain and spinal cord) doesn't have room to expand during inflammation (a natural result of any infection). inflammation causes more fluid to increase pressure in your CNS. this can lead to herniation of your brain through the foramen magnum, where your spinal cord enters your skull, which in turn can lead to coma and death. It is possible to see increased levels of Ab (specifically IgG, a type of Ab) with MS. however, you can also see it with almost any type of bacterial meningitis, and even sometimes with viral meningitis. (meningitis is inflammation of the layers that protect the brain and spinal cord) good luck on your case presentation. if you have other questions email me soon.
Antibodies are in blood, they don't cross the blood/brain barrier, and there shouldn't be any blood in CSF, except for cases of infections.
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Answers:
Antibodies induce an inflammatory response when you have an infection. Your CSF doesn't contain antibodies (Abs) because unlike your body, your central nervous system (CNS:brain and spinal cord) doesn't have room to expand during inflammation (a natural result of any infection). inflammation causes more fluid to increase pressure in your CNS. this can lead to herniation of your brain through the foramen magnum, where your spinal cord enters your skull, which in turn can lead to coma and death. It is possible to see increased levels of Ab (specifically IgG, a type of Ab) with MS. however, you can also see it with almost any type of bacterial meningitis, and even sometimes with viral meningitis. (meningitis is inflammation of the layers that protect the brain and spinal cord) good luck on your case presentation. if you have other questions email me soon.
Antibodies are in blood, they don't cross the blood/brain barrier, and there shouldn't be any blood in CSF, except for cases of infections.
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